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A Magnetic Adsorbent Grafted With Pendant Naphthyl Polymer Brush for Enrichment of the Nonsteroidal Anti-Inflammatory Drugs Indomethacin and Diclofenac

A Magnetic Adsorbent Grafted With Pendant Naphthyl Polymer Brush for Enrichment of the Nonsteroidal Anti-Inflammatory Drugs Indomethacin and Diclofenac

Ya'nan Deng, Jiwei Shen, Jiawei Liu, Yinmao Wei, Chaozhan Wang

Mikrochim Acta. 2018 Jul 9;185(8):370.

PMID: 29987393

Abstract:

Poly(2-naphthyl acrylate) was first grafted onto silica-coated magnetic nanoparticles by surface-initiated atom transfer radical polymerization to prepare a reversed-phase magnetic adsorbent. The resulting polymer brush displays enhanced extraction efficiency by offering active sites on the surfaces of adsorbent. It was applied to the preconcentration of the non-steroidal antiinflammatory drugs (NSAIDs) indomethacin (InDo) and diclofenac (DIC). These drugs interact with the sorbent through hydrophobic and π-interactions, and via electrostatic attraction. By coupling the magnetic solid-phase extraction with HPLC, a method for analysis of InDo and DIC in the environmental water samples was established. The limits of detection range from 0.62 to 0.64 ng·mL-1, and the relative standard deviations for intra-and inter-day analyses of spiked water samples are <11.9%, and relative recoveries are between 62.1 and 96.7%. Graphical abstract A reversed-phase magnetic adsorbent was prepared by grafting poly(2-naphthyl acrylate) brush on the surface of silica coated magnetic nanoparticles. Due to the two conjugated aromatic rings of the monomer, the polymer brush can effectively extract non-steroidal anti-inflammatory drugs through strong π- and hydrophobic interactions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP52684341	2-Naphthyl acrylate		52684-34-1	Price
LS775175	Poly(2-naphthyl acrylate)			Price

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