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A Method Developed for Determination of Heptachlor and Its Metabolites From Pork

A Method Developed for Determination of Heptachlor and Its Metabolites From Pork

Hai Gen Zuo, Jian Xin Zhu, Chun Rui Zhan, Guo Yan Tang, Ping Guo, Yuan Long Wei, Hai Long Zeng, Hong Yang

Environ Monit Assess. 2014 Apr;186(4):2399-412.

PMID: 24337977

Abstract:

A new method has been developed to determine heptachlor and its metabolites heptachlor-exo-epoxide and heptachlor-endo-epoxide in pork. The pork samples were extracted with acetone-n-hexane (2:8, V:V) and cleaned up by gel permeation chromatography and florisil solid-phase extraction cartridge. The extract was then determined by gas chromatography equipped with electron capture detector (GC-ECD), followed by validation using gas chromatography-mass spectrometry (GC-MS) with negative chemical ionization. Linearity of calibration curves ranged from 0.01 to 0.5 mg L(-1), with correlation coefficients of more than 0.9980 for GC-ECD and GC-MS, respectively. At spiked concentrations of 0.01, 0.05, and 0.1 mg kg(-1), the average recovery and relative standard deviation values were 87.1-102.2 and 4.0-11.3%, respectively. The limit of quantification for each analyte was 0.01 mg kg(-1), which satisfied the current maximum residue limit permitted in pork. Our results showed that the method developed was successfully used to determine heptachlor and heptachlor epoxide residues in real pork samples.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28044839-A	Heptachlor endo-epoxide		28044-83-9	Price

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