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A Monoclonal Anti-Idiotypic Antibody Against a Human Monoclonal IgM With Specificity for Myelin-Associated Glycoprotein

A Monoclonal Anti-Idiotypic Antibody Against a Human Monoclonal IgM With Specificity for Myelin-Associated Glycoprotein

N Page, N Murray, G Perruisseau, A J Steck

J Immunol. 1985 May;134(5):3094-9.

PMID: 2580012

Abstract:

A human monoclonal IgM lambda antibody, directed against MAG, obtained from a patient with polyneuropathy associated with a gammopathy, was used as an immunogen to generate mouse monoclonal anti-idiotype antibodies. One hybridoma antibody, designated A8F2, reacts uniquely with the M-IgM of the patient, shows high affinity binding to the patient's M-IgM, and dose-dependently inhibits binding of the patient's M-IgM to its specific antigen MAG. Thus, A8F2 is a monoclonal anti-idiotype antibody that recognizes a region of the MAG binding site of the patient's IgM. Use of this anti-idiotype antibody in a competition RIA revealed the presence of naturally occurring anti-idiotype in the patient's serum. Because anti-idiotype antibodies may be part of a mechanism for down-regulation of antibody production, the use of A8F2 to induce a specific immunosuppression should be considered.

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