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A Multihit Model: Colitis Lessons From the Interleukin-10-deficient Mouse

A Multihit Model: Colitis Lessons From the Interleukin-10-deficient Mouse

Lydia M Keubler, Manuela Buettner, Christine Häger, André Bleich

Inflamm Bowel Dis. 2015 Aug;21(8):1967-75.

PMID: 26164667

Abstract:

Complex mechanisms are pulling the strings to initiate the development of inflammatory bowel disease. Current evidence indicates that an interaction of genetic susceptibilities (polymorphisms), environmental factors, and the host microbiota leads to a dysregulation of the mucosal immune system. In the past decades, the interleukin-10-deficient mouse has served as an excellent model to mirror the multifactorial nature of this disease. Here, we want to review in detail the interplay of the genetic factors, immune aspects, and especially summarize and discuss the role of the microbiota contributing to colitis development in the interleukin-10-deficient mouse model of inflammatory bowel disease as a multihit model.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413334	Interleukin-10 from mouse			Price

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