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A Negative Correlation Between Water Content and Protein Adsorption on Polymer Brushes

A Negative Correlation Between Water Content and Protein Adsorption on Polymer Brushes

Wei Dai, Cong Zheng, Bintao Zhao, Kuo Chen, Pengxiang Jia, Jingfa Yang, Jiang Zhao

J Mater Chem B. 2019 Apr 7;7(13):2162-2168.

PMID: 32073575

Abstract:

The correlation between the water content and protein adsorption on the surface of polymer brushes is investigated quantitatively. Using a number of model systems such as poly N-isopropylacrylamide (PNIPAM), polyethylene glycol (PEG), poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), poly(2-hydroxyethyl methacrylate) (PHEMA), and poly(2,2,3,4,4,4-hexafluorobutyl)methacrylate (PHFBMA) polymer brushes with various grafting densities, the amount of water hydrodynamically coupled inside the brushes and its correlation with protein adsorption (BSA and Fg proteins as model systems) were determined by quartz crystal microbalance with dissipation (QCM-D) and surface plasma resonance (SPR). The results demonstrate the negative correlation between the water content and protein adsorption - the more water is coupled inside the brushes, the more protein adsorption is suppressed. In particular for PNIPAM brushes with a high enough grafting density and with a water content greater than 250 ng cm-2, the protein adsorption is negligible.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36405477	2,2,3,4,4,4-Hexafluorobutyl methacrylate		36405-47-7	Price
AP64376869	Poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)		64376-86-9	Price

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