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A New Antibacterial silver(I) Complex Incorporating 2,5-dimethylpyrazine and the Anti-Inflammatory Diclofenac

A New Antibacterial silver(I) Complex Incorporating 2,5-dimethylpyrazine and the Anti-Inflammatory Diclofenac

Sevim Hamamci Alisir, Necmi Dege

Acta Crystallogr C Struct Chem. 2016 Dec 1;72(Pt 12):947-951.

PMID: 27918295

Abstract:

AgI-containing coordination complexes have attracted attention because of their photoluminescence properties and antimicrobial activities and, in principle, these properties depend on the nature of the structural topologies. A novel two-dimensional silver(I) complex with the anti-inflammatory diclofenac molecule, namely bis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ3O,O':O}bis(μ-2,5-dimethylpyrazine-κ2N:N')silver(I), [Ag2(C14H10Cl2NO2)2(C6H8N2)]n, (I), has been synthesized and characterized by single-crystal X-ray diffraction, revealing that the AgI ions are chelated by the carboxylate groups of the anionic 2-[2-(2,6-dichloroanilino)phenyl]acetate (dicl) ligand in a μ3-η1:η2 coordination mode. Each dicl ligand links three AgI atoms to generate a one-dimensional infinite chain. Adjacent chains are connected through 2,5-dimethylpyrazine (dmpyz) ligands to form a two-dimensional layer structure parallel to the crystallographic bc plane. The layers are further connected by C-H...π interactions to generate a three-dimensional supramolecular structure. Additionally, the most striking feature is that the structure contains an intramolecular C-H ...Ag anagostic interaction. Furthermore, the title complex has been tested for its in vitro antibacterial activity and is determined to be highly effective on the studied microorganisms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP123320	2,5-Dimethylpyrazine		123-32-0	Price

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