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A New Antitumour Ansamitocin From Actinosynnema Pretiosum

Guo-Zhu Wei, Lin-Quan Bai, Tao Yang, Juan Ma, Ying Zeng, Yue-Mao Shen, Pei-Ji Zhao

Nat Prod Res. 2010 Jul;24(12):1146-50.

PMID: 20582809

Abstract:

A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP66584723 Ansamitocin P-3 from Actinosynnema pretiosum Ansamitocin P-3 from Actinosynnema pretiosum 66584-72-3 Price
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