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A New Inhibitor of Protein Kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and Biological Activity

A New Inhibitor of Protein Kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and Biological Activity

H Osada, H Koshino, T Kudo, R Onose, K Isono

J Antibiot (Tokyo). 1992 Feb;45(2):189-94.

PMID: 1556009

Abstract:

A novel inhibitor of protein kinase C was found in the fermentation of a soil actinomycete, strain RK-1409. According to the taxonomic studies, the producing strain was designated as Streptomyces platensis subsp. malvinus RK-1409. The protein kinase C inhibitor, RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human chronic erythroleukemia cell, K-562, induced by phorbol 12,13-dibutyrate (PDBu) at the concentration of 10 ng/ml. The concentration of 3 ng/ml inhibited the activity of protein kinase C in vitro. RK-1409 inhibited the cell cycle progression at G2 phase of K-562 cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP125035838	7-Oxostaurosporine		125035-83-8	Price

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