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A New Mild Synthetic Route to N-arylated Pyridazinones From Aryldiazonium Salts

Ouissam El Bakouri, Daniel Cassú, Miquel Solà, Teodor Parella, Anna Pla-Quintana, Anna Roglans

Chem Commun (Camb). 2014 Jul 28;50(59):8073-6.

PMID: 24923410

Abstract:

An efficient method for the synthesis of N-arylated pyridazinones from potassium 2-furantrifluoroborate and aryldiazonium salts is described. The reaction was run in water at 0-5 °C in short reaction times and without any catalyst or additive. A mechanistic proposal is made based on the experimental data and DFT calculations.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP166328149 Potassium 2-furantrifluoroborate Potassium 2-furantrifluoroborate 166328-14-9 Price
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