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A New Polymer Concept for Coating of Vascular Stents Using PTFEP (Poly(bis(trifluoroethoxy)phosphazene) to Reduce Thrombogenicity and Late In-Stent Stenosis

A New Polymer Concept for Coating of Vascular Stents Using PTFEP (Poly(bis(trifluoroethoxy)phosphazene) to Reduce Thrombogenicity and Late In-Stent Stenosis

Goetz M Richter, Ulrike Stampfl, Sibylle Stampfl, Christoph Rehnitz, Susann Holler, Philip Schnabel, Michael Grunze

Invest Radiol. 2005 Apr;40(4):210-8.

PMID: 15770139

Abstract:

Objectives:
We sought to evaluate the new polymer PTFEP (poly(bis(trifluoroethoxy)phosphazene) for (1) its ability to reduce thrombogenicity and late in-stent stenosis and (2) its effect on endothelialization in a rabbit iliac artery model.
Materials and methods:
Nanocoated ( approximately 50 nm) and bare stainless-steel stents were implanted bilaterally in the iliac arteries of 30 New Zealand White rabbits (1, 4, 8, 12, and 16 weeks follow-up) and evaluated by angiography, light, and scanning electron microscopy.
Results:
Bilateral stent placement was successful in 27 of 30 rabbits. Thrombus depositions occurred in none of the 27 coated but in 4 of the 27 bare stents (P=0.037). A normal angiogram was obtained in 18 of 22 coated stents at risk for restenosis (follow-up >or=4 weeks) but only in 13 of 22 bare stents (P=0.023). Marked restenosis (luminal loss >30%) was found in 6 bare stents (P=0.011) but not in any coated stents. The neointima was 47.7-73.9 mum on coated and 66.9-115.2 mum on bare stents (statistically significant at 4, 8, and 16 weeks). Scanning electron microscopy detected full endothelialization in all stents from 4 weeks on (22 stents in both groups).
Conclusion:
PTFEP nanocoating successfully showed thromboresistance and reduced late in-stent stenosis. Endothelialization was equal in both stent types. Studies in more human-like models and human feasibility studies in human arteries are encouraged.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS775300	Poly(bis(1,4,7-trioxaoctyl)phosphazene)			Price

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