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A Novel Action of Terpendole E on the Motor Activity of Mitotic Kinesin Eg5

A Novel Action of Terpendole E on the Motor Activity of Mitotic Kinesin Eg5

Junko Nakazawa, Junichiro Yajima, Takeo Usui, Masashi Ueki, Akira Takatsuki, Masaya Imoto, Yoko Y Toyoshima, Hiroyuki Osada

Chem Biol. 2003 Feb;10(2):131-7.

PMID: 12618185

Abstract:

To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E (TerE) as a novel Eg5 inhibitor. TerE did not affect microtubule integrity in interphase, but induced formation of a monoastral spindle in M phase. TerE inhibited both motor and microtubule-stimulated ATPase activities of human Eg5, but did not affect conventional kinesin from either Drosophila or bovine brain. Although terpendoles have been reported as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT), the Eg5 inhibitory activity of TerE was independent of ACAT inhibition. Taken together, we demonstrate that TerE is a novel Eg5 inhibitor isolated from a fungal strain.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP167427238	Terpendole E		167427-23-8	Price

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