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A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery

Sílvia Santos Pedrosa, Catarina Gonçalves, Laurent David, Miguel Gama

Macromol Biosci. 2014 Nov;14(11):1556-68.

PMID: 25088667

Abstract:

An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker-1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP141647623 1,4-Bis[3-(2-pyridyldithio)propionamido]butane 1,4-Bis[3-(2-pyridyldithio)propionamido]butane 141647-62-3 Price
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