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A Novel Curcumin-Loaded Nanoparticle Restricts Atherosclerosis Development and Promotes Plaques Stability in Apolipoprotein E Deficient Mice

A Novel Curcumin-Loaded Nanoparticle Restricts Atherosclerosis Development and Promotes Plaques Stability in Apolipoprotein E Deficient Mice

Ning Meng, Yan Gong, Jiefeng Zhang, Xin Mu, Zhimei Song, Runliang Feng, Hua Zhang

J Biomater Appl. 2019 Feb;33(7):946-954.

PMID: 30541364

Abstract:

Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E-/- mice. Our results demonstrated that the Cur-NPs significantly decreased atherosclerotic lesion areas and were more effective in stabilizing vulnerable plaques compared with free curcumin. The anti-atherosclerotic mechanisms of Cur-NPs include decreasing the number of introplaque microvessels, inhibiting the matrix metalloproteinase 2 and 9 activity, reducing the inflammatory response and regulating lipoprotein cholesterol metabolism more effectively compared with free curcumin. Furthermore, Cur-NPs could increase the amount of curcumin in the thoracic aorta and no significant toxicity was observed in the blood biochemical parameters in Cur-NPs-treated groups. Overall, our findings suggested that Cur-NPs could be a stabilized aqueous formulation for application with improved curcumin activity, which could be a potential treatment strategy for arteriosclerosis in the future.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS76214	Poly(ethylene glycol) linear dendrimer			Price

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