Home
Resources
Publications
A Novel Function of Geranylgeraniol in Regulating Testosterone Production

A Novel Function of Geranylgeraniol in Regulating Testosterone Production

Hsin-Jung Ho, Hitoshi Shirakawa, Puspo E Giriwono, Asagi Ito, Michio Komai

Biosci Biotechnol Biochem. 2018 Jun;82(6):956-962.

PMID: 29303051

Abstract:

Isoprenoids play widely differing roles in various physiological processes in animals and plants. Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid/cholesterol synthesis pathway. Earlier studies focused on GGOH's ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities. It is noteworthy that GGOH regulates the steroidogenesis pathway in testis-derived I-10 tumor cells. Testosterone is a hormone produced via steroidogenesis in testicles and plays a role in fetal development and the male reproductive system. GGOH enhanced testosterone and progesterone (its precursor) levels in I-10 cells by activating adenylate cyclase via cAMP/PKA signaling, without altering phosphodiesterase activity. These findings highlight the potential benefits of GGOH as a therapeutic agent for low testosterone levels, such as late-onset hypogonadism in men.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24034739	Geranylgeraniol		24034-73-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: