Home
Resources
Publications
A Novel Mechanism of Immunity Controls the Onset of Cinnamycin Biosynthesis in Streptomyces Cinnamoneus DSM 40646

A Novel Mechanism of Immunity Controls the Onset of Cinnamycin Biosynthesis in Streptomyces Cinnamoneus DSM 40646

Sean O'Rourke, David Widdick, Mervyn Bibb

J Ind Microbiol Biotechnol. 2017 May;44(4-5):563-572.

PMID: 27858169

Abstract:

Streptomyces cinnamoneus DSM 40646 produces the Class II lantibiotic cinnamycin which possesses an unusual mechanism of action, binding to the membrane lipid phosphatidylethanolamine (PE) to elicit its antimicrobial activity. A comprehensive analysis of the cinnamycin biosynthetic gene cluster has unveiled a novel mechanism of immunity in which the producing organism methylates its entire complement of PE prior to the onset of cinnamycin production. Deletion of the PE methyl transferase gene cinorf10, or the two-component regulatory system (cinKR) that controls its expression, leads not only to sensitivity to the closely related lantibiotic duramycin, but also abolishes cinnamycin production, presumably reflecting a fail-safe mechanism that serves to ensure that biosynthesis does not occur until immunity has been established.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP110655588	Cinnamycin		110655-58-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: