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A Novel Mouse Monoclonal Antibody Targeting ErbB2 Suppresses Breast Cancer Growth

A Novel Mouse Monoclonal Antibody Targeting ErbB2 Suppresses Breast Cancer Growth

Seiji Kawa, Hirohisa Matsushita, Hirokazu Ohbayashi, Kentaro Semba, Tadashi Yamamoto

Biochem Biophys Res Commun. 2009 Jul 3;384(3):329-33.

PMID: 19409371

Abstract:

Overexpression of ErbB2 in breast cancer is associated with increased recurrence and worse prognosis. Accumulating evidences suggest that molecular targeted therapy is a promising anticancer strategy. In this study, we produced a novel anti-ErbB2 monoclonal antibody, 6G10, that recognized an epitope distinct from the trastuzumab binding site. 6G10 induced aggregation of BT474 breast cancer cells and inhibited proliferation of various breast cancer cell lines including BT474. A growth inhibition assay showed that 6G10 had EC(50) values comparable to trastuzumab, indicating that the drugs have a similar level of potency. Furthermore, intraperitoneal administration of 6G10 completely inhibited the growth of xenografted tumors derived from BT474 and SK-BR-3 cells. These data suggested that 6G10 has great therapeutic potential and could be administered to patients alternatively, or synergistically, with trastuzumab.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413570	Monoclonal Anti-ERBB2 antibody produced in mouse			Price

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