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A Novel, Non-High-Dilution Method for Preparation of 1,1,2,2,9,9,10,10-Octafluoro

WR Dolbier Jr, JX Duan, AJ Roche

Org Lett. 2000 Jun 29;2(13):1867-1869.

PMID: 10891178

Abstract:

A novel synthesis of octafluoro[2.2]paracyclophane (AF4), one that remarkably does not require the use of high dilution methodology, is presented. Using this unprecedented methodology, AF4 is produced in 60% yield in a reaction of Zn with 0.35 M p-bis(chlorodifluoromethyl)benzene in DMA at 100 degrees C. The process comprises a convenient, inexpensive, and highly scaleable preparation of AF4 for both research and commercial purposes.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3345297 1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane 1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane 3345-29-7 Price
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