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A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells Into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells

Jungwoon Lee, Yan Xia, Mi-Young Son, Guanghai Jin, Binna Seol, Min-Jeong Kim, Myung Jin Son, Misol Do, Minho Lee, Dongsup Kim, Kyeong Lee, Yee Sook Cho

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13.

PMID: 23125037

Abstract:

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1418131460 RSC133 RSC133 1418131-46-0 Price
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