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A Novel Spectrophotometric Method for the Determination Oxacillin Sodium

A Novel Spectrophotometric Method for the Determination Oxacillin Sodium

Rajinder Singh Gujral, Sk Manirul Haque, Prem Shanker

Int J Biomed Sci. 2009 Dec;5(4):373-9.

PMID: 23675161

Abstract:

A simple and sensitive spectrophotometric method was developed for the determination of Oxacillin sodium. The method was based on charge transfer complexation reaction of the drug with iodine in methanol - dichloromethane medium. The absorbance was measured at 365 nm against the reagent blank. Under optimized experimental conditions, Beer's law is obeyed in the concentration ranges 2-8 μg/ml for Oxacillin Sodium. The method was validated for specificity, linearity, precision, accuracy, limit of quantitation, robustness and ruggedness. The LOD and LOQ value were 0.39 and 1.18 μg/ml respectively. The method was successfully applied to the analysis of Oxacillin sodium in Human Urine samples with good accuracy and precision.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7240382	Oxacillin sodium		7240-38-2	Price

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