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A Perspective on the Epidemiology of Acetaminophen Exposure and Toxicity in the United States

A Perspective on the Epidemiology of Acetaminophen Exposure and Toxicity in the United States

Marissa Blieden, L Clark Paramore, Dhvani Shah, Rami Ben-Joseph

Expert Rev Clin Pharmacol. 2014 May;7(3):341-8.

PMID: 24678654

Abstract:

Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity. Recent FDA and CMS decisions serve to limit and monitor exposure to high-dose acetaminophen. This literature review aims to describe the exposure to and consequences of high-dose acetaminophen among chronic pain patients in the US. Each year in the US, approximately 6% of adults are prescribed acetaminophen doses of more than 4 g/day and 30,000 patients are hospitalized for acetaminophen toxicity. Up to half of acetaminophen overdoses are unintentional, largely related to opioid-acetaminophen combinations and attempts to achieve better symptom relief. Liver injury occurs in 17% of adults with unintentional acetaminophen overdose.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103902-A	Acetaminophen		103-90-2	Price

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