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A Phenylpyruvic Acid Reductase Is Required for Biosynthesis of Tropane Alkaloids

Fei Qiu, Chunxian Yang, Lina Yuan, Dan Xiang, Xiaozhong Lan, Min Chen, Zhihua Liao

Org Lett. 2018 Dec 21;20(24):7807-7810.

PMID: 30511859

Abstract:

Solanaceous medicinal plants produce tropane alkaloids (TAs). We discovered a novel gene from Atropa belladonna, AbPPAR, which encodes a phenylpyruvic acid reductase required for TA biosynthesis. AbPPAR was specifically expressed in root pericycles and endodermis. AbPPAR was shown to catalyze reduction of phenylpyruvic acid to phenyllactic acid, a precursor of TAs. Suppression of AbPPAR disrupted TA biosynthesis through reduction of phenyllactic acid levels. In summary, we identified a novel enzyme involved in TA biosynthesis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP156069 Phenylpyruvic acid Phenylpyruvic acid 156-06-9 Price
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