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A Possible Immunosuppressant, Cycloprodigiosin Hydrochloride, Obtained From Pseudoalteromonas Denitrificans

A Possible Immunosuppressant, Cycloprodigiosin Hydrochloride, Obtained From Pseudoalteromonas Denitrificans

K Kawauchi, K Shibutani, H Yagisawa, H Kamata, S Nakatsuji, H Anzai, Y Yokoyama, Y Ikegami, Y Moriyama, H Hirata

Biochem Biophys Res Commun. 1997 Aug 28;237(3):543-7.

PMID: 9299400

Abstract:

Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide dependent 3H-thymidine incorporation, indicating that cPrG.HCl acts as a selective inhibitor of T cell proliferation in the same way as other members of the prodigiosin family. cPrG.HCl inhibited the proliferation of the PMA stimulated Jurkat cells through an apoptotic process. Intriguingly, cPrG.HCl inhibited the H+ translocation by vacuolar type ATPase in chromaffin granule membranes without any effect on either its ATPase activity nor on the membrane conductance of phospholipid bilayers, suggesting that cPrG.HCl selectively uncouples H+ translocation from the ATPase reaction rather than acting as a non-specific ionophore. Since crystalline cPrG.HCl is highly stable, it raises the possibility of its therapeutic use as an immunosuppressant.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP56144173	Prodigiosin hydrochloride		56144-17-3	Price

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