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A Preliminary Study on Intravenous Infusion of Sodium Eicosapentaenoate

Y Liu, D Chen

Drug Dev Ind Pharm. 2000 Feb;26(2):189-91.

PMID: 10697755

Abstract:

Eicosapentaenoic acid (EPA) and arachidonic acid (AA), made into sodium salt solution (50 micrograms/ml), were used for intravenous infusion. In a preclinical study in dogs, Na-EPA lowered the activity of transminases (glutamic pyruvic transaminase [GPT], glytamic oxaloacetic transaminase [GOT]); however, Na-AA increased the activity of GPT and GOT. In the clinical study, the numbers of leukocytes and lymphocytes of volunteers increased and remained at that level for 3 to 5 days after intravenous infusion. The study indicated that an intravenous infusion of Na-EPA may have anti-inflammatory and immunomodulatory effects.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP24435254 NAEPA NAEPA 24435-25-4 Price
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