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A Preliminary Study on L-Lysine Fermentation From Lignocellulose Feedstock and Techno-Economic Evaluation

A Preliminary Study on L-Lysine Fermentation From Lignocellulose Feedstock and Techno-Economic Evaluation

Zeyu Chen, Gang Liu, Jian Zhang, Jie Bao

Bioresour Technol. 2019 Jan;271:196-201.

PMID: 30268811

Abstract:

l-Lysine is a commodity amino acid produced from starch feedstock. Various alternative feedstocks had been used for l-lysine production, but the yield was very low. This study took the first preliminary investigation on l-lysine production from lignocellulose for the replacement of food-crop starch. Corn stover was dry acid pretreated and biodetoxified, then used for enzymatic hydrolysis and l-lysine fermentation by an industrial Corynebacterium glutamicum strain. Various fermentation parameters, nutrient additions, and operation variables were applied and finally 33.8 g/L of l-lysine was obtained. This l-lysine titer is still below that of starch based fermentation, but already 3-5 folds greater than that of other alternative feedstocks based fermentation. A techno-economic analysis was conducted and the minimum selling price of l-lysine (hydrochloride form) was calculated to be $2.445 per kg. The cost reduction by the future improvement could fill the technical and economic gap between the cellulosic and starch based l-lysine production.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP657272-B	L-Lysine hydrochloride		657-27-2	Price

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