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A Randomized Controlled Trial Comparing the Efficacy of 1-L Polyethylene Glycol Solution With Ascorbic Acid Plus Prucalopride Versus 2-L Polyethylene Glycol Solution With Ascorbic Acid for Bowel Preparation

A Randomized Controlled Trial Comparing the Efficacy of 1-L Polyethylene Glycol Solution With Ascorbic Acid Plus Prucalopride Versus 2-L Polyethylene Glycol Solution With Ascorbic Acid for Bowel Preparation

Seong Ji Choi, Eun Sun Kim, Byeong Kwang Choi, Geeho Min, Woojung Kim, Jung Min Lee, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Bora Keum, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim

Scand J Gastroenterol. 2018 Dec;53(12):1619-1624.

PMID: 30621479

Abstract:

Objectives:
Bowel cleansing is a major patient complaint during colonoscopy. Adding laxatives to the bowel preparation is effective in replacing a portion of bowel preparation solution and reducing its volume. Prucalopride is a serotonin receptor agonist that stimulates gastrointestinal motility and provides propulsive force for defecation. This study aimed to compare 1 L polyethylene glycol (PEG) with ascorbic acid (Asc) plus 2 mg prucalopride (1LP/AP) and 2 L PEG with Asc (2LP/A) for colonoscopy preparation with respect to bowel-cleansing quality and side effects.
Methods:
A single-center, randomized, prospective study was conducted with 260 outpatients administered either 1LP/AP or 2LP/A. The primary endpoint was bowel preparation quality, which was evaluated using the Boston Bowel Preparation Scale and Aronchick Bowel Preparation Scale, and the secondary endpoints were patient tolerability and acceptability, assessed by a questionnaire-based survey.
Results:
The adequate bowel preparation rates were 88.5% and 83.1% in the 2LP/A and 1LP/AP groups, respectively, and the efficacy of 1LP/AP was equivalent to the control regimen (p=.216). Other colonoscopic variables including adenoma detection rate were similar in both groups. Patient tolerability and acceptability were not significantly different, but patients in the 1LP/AP group were more willing to repeat the same regimen (p=.039).
Conclusions:
Bowel preparation quality with 1LP/AP was equivalent to that with 2LP/A, which did not increase the occurrence of side effects, but it reduced the volume of the solution ingested, and increased patient satisfaction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25322683-P	Polyethylene glycol solution		25322-68-3	Price

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