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A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Hongkun Lin, Chunhui Dai, Timothy F Jamison, Klavs F Jensen

Angew Chem Int Ed Engl. 2017 Jul 17;56(30):8870-8873.

PMID: 28561939

Abstract:

Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overall yield of the eight-step sequence was 60 %. No separation of intermediates was required throughout the synthesis when a single acylation reaction was applied to remove the main byproduct, dimethylamine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP86393320-B	Ciprofloxacin hydrochloride		86393-32-0	Price

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