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A Review of Flavoxate Hydrochloride in the Treatment of Urge Incontinence

R Ruffmann

J Int Med Res. Sep-Oct 1988;16(5):317-30.

PMID: 2461883

Abstract:

This article provides a review of the use of flavoxate hydrochloride in the treatment of urge incontinence. It outlines the pharmacology, mode of action, toxicology and pharmacokinetic studies which have been carried out, and then reviews the clinical studies, including those involving patients with benign prostatic hypertrophy. The effects of dosages of 600-1200 mg/day are compared, particularly regarding safety and tolerability factors. Finally, alternative therapies to flavoxate hydrochloride (alpha-adrenergic receptor blockers, oxybutinin chloride, terodiline hydrochloride, emepronium bromide and imipramine) are summarized. The article is written in the knowledge of recent evidence which indicates that flavoxate hydrochloride exhibits only weak anticholinergic activity on receptors involved in the control of the lower urinary tract.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3717882-A Flavoxate hydrochloride Flavoxate hydrochloride 3717-88-2 Price
AP7082215 Terodiline hydrochloride Terodiline hydrochloride 7082-21-5 Price
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