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A Selective ALDH-2 Inhibitor Reduces Anxiety in Rats

A Selective ALDH-2 Inhibitor Reduces Anxiety in Rats

David H Overstreet, Darin J Knapp, George R Breese, Ivan Diamond

Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

PMID: 19747934

Abstract:

CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 that reduces excessive alcohol drinking. Anxiety plays a role in alcoholism. The present study asks whether CVT-10216 has anxiolytic properties, as reflected in social interaction behavior in four unrelated rodent models: endogenous anxiety-like behavior in naïve Fawn-Hooded rats, repeated alcohol-withdrawal-induced anxiety, restraint stress-induced anxiety and drug-induced anxiety. CVT-10216 counteracted anxiety in all models except that produced by the 5-HT(2C) agonist, mCPP. CVT-10216 exhibited both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety. Importantly, anxiogenic behavior induced by the benzodiazepine receptor inverse agonist, DMCM, was counteracted dose-dependently by CVT-10216. Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1005334575	CVT-10216		1005334-57-5	Price

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