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A Short-Chain Peptide Toxin Isolated From Centruroides Sculpturatus Scorpion Venom Inhibits ether-à-go-go-related Gene K(+) Channels

A Short-Chain Peptide Toxin Isolated From Centruroides Sculpturatus Scorpion Venom Inhibits ether-à-go-go-related Gene K(+) Channels

W Nastainczyk, H Meves, D D Watt

Toxicon. 2002 Jul;40(7):1053-8.

PMID: 12076661

Abstract:

From the venom of the American scorpion Centruroides sculpturatus Ewing we have isolated a minute peptide fraction (named CsEKerg1) which reversibly inhibits the current through ERG (ether-à-go-go-related gene) K(+) channels. Isolation was done by CM-cellulose column chromatography and reversed phase high-performance liquid chromatography. To test for an effect on ERG channels we used NG108-15 neuroblastomaxglioma hybrid cells voltage-clamped in the whole-cell mode. CsEKerg1 contains 43 amino acids and has a molecular weight of 4833. Its amino acid sequence is similar but not identical to that of ergtoxin, a peptide isolated recently from the venom of the Mexican scorpion Centruroides noxius [FASEB J. 13 (1999) 953]. Half inhibition of ERG current occurs at a peptide concentration of 1.12microg/ml.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4245250	Scorpion venom from Centruroides sculpturatus			Price
IAR4246951	Ergtoxin from Centruroides noxius (Scorpion)			Price

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