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A Simple Effective Method for Estimating the [18O] Enrichment of Water Mixtures

A Simple Effective Method for Estimating the [18O] Enrichment of Water Mixtures

Richard M Fawdry

Appl Radiat Isot. 2004 Jan;60(1):23-6.

PMID: 14687632

Abstract:

Isotopically enriched water, [18O] H(2)O, recovered from the synthesis of [18F] fluorine-labelled PET radiopharmaceuticals, is frequently diluted with natural water, [16O] H(2)O. The extent of isotope dilution limits the usefulness of the recovered water. A simple method for determining the [18O] enrichment of water mixtures could aid PET cyclotron facilities to calculate the [18F] yields to be expected when the recovered [18O] H(2)O is reused. A gravimetric method (repeatability for high enrichment +/-0.3% [18O], detection limit approximately 2% [18O] enrichment) is described.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14314422	Water-18O		14314-42-2	Price

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