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A Single Intrauterine Injection of the Serine Protease Inhibitor 4-(2-aminoethyl)benzenesulfonyl Fluoride Hydrochloride Reversibly Inhibits Embryo Implantation in Mice

A Single Intrauterine Injection of the Serine Protease Inhibitor 4-(2-aminoethyl)benzenesulfonyl Fluoride Hydrochloride Reversibly Inhibits Embryo Implantation in Mice

Zhao-gui Sun, Hui-juan Shi, Zheng Gu, Jian Wang, Qing-xiang Shen

Contraception. 2007 Sep;76(3):250-5.

PMID: 17707725

Abstract:

Background:
The study was conducted to investigate the inhibitory effect of 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) on embryo implantation in mice with a view to identifying whether it might be a suitable agent for postcoital contraception.
Study design:
The anti-implantation efficacy of AEBSF was determined by counting the number of visible implanted embryos on Day 8 of pregnancy following a single intrauterine injection of AEBSF at doses of 30, 300 and 3000 microg per mouse uterine horn on Day 3 of pregnancy. The reversibility of the inhibitory effect of AEBSF on implantation was further evaluated by observing the outcome of a subsequent pregnancy without AEBSF treatment.
Results:
A dose-dependent inhibitory effect of AEBSF on embryo implantation in vivo was observed. Morphological analysis revealed no significant cytotoxicity of AEBSF on the mouse uterine epithelia. Furthermore, the anti-implantation effect of AEBSF was reversible.
Conclusion:
Intrauterine administration of AEBSF at an appropriate dose might provide a basis for the development of novel contraception.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30827997-A	4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride		30827-99-7	Price
AP651293082	Serine Hydrolase Inhibitor-4		651293-08-2	Price

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