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A Small Molecule Modulates Circadian Rhythms Through Phosphorylation of the Period Protein

Jae Wook Lee, Tsuyoshi Hirota, Eric C Peters, Michael Garcia, Rodolfo Gonzalez, Charles Y Cho, Xu Wu, Peter G Schultz, Steve A Kay

Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.

PMID: 21954091

Abstract:

Time shift:
A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP639052781 LH846 LH846 639052-78-1 Price
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