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A Small-Molecule TrkB Ligand Restores Hippocampal Synaptic Plasticity and Object Location Memory in Rett Syndrome Mice

A Small-Molecule TrkB Ligand Restores Hippocampal Synaptic Plasticity and Object Location Memory in Rett Syndrome Mice

Wei Li, Alba Bellot-Saez, Mary L Phillips, Tao Yang, Frank M Longo, Lucas Pozzo-Miller

Dis Model Mech. 2017 Jul 1;10(7):837-845.

PMID: 28679669

Abstract:

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficient mice. Furthermore, experimental interventions that increase BDNF levels improve RTT-like phenotypes in Mecp2 mutant mice. Here, we characterized the actions of a small-molecule ligand of the BDNF receptor TrkB in hippocampal function in Mecp2 mutant mice. Systemic treatment of female Mecp2 heterozygous (HET) mice with LM22A-4 for 4 weeks improved hippocampal-dependent object location memory and restored hippocampal long-term potentiation (LTP). Mechanistically, LM22A-4 acts to dampen hyperactive hippocampal network activity, reduce the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs), and reduce the frequency of spontaneous tetrodotoxin-resistant Ca2+ signals in Mecp2 mutant hippocampal neurons, making them comparable to those features observed in wild-type neurons. Together, these observations indicate that LM22A-4 is a promising therapeutic candidate for the treatment of hippocampal dysfunction in RTT.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP37988184	LM22A-4		37988-18-4	Price

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