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A Static Magnetic Field Inhibits the Expression of Platelet-Derived Growth factor-AA in Human Oral Squamous Cell Carcinoma

A Static Magnetic Field Inhibits the Expression of Platelet-Derived Growth factor-AA in Human Oral Squamous Cell Carcinoma

Miho Obayashi-Ishii, Satsuki Saito, Daisuke Omagari, Masatake Asano, Tomohiko Ishigami

J Oral Sci. 2018 Sep 23;60(3):374-380.

PMID: 30146536

Abstract:

Magnetic attachments are commonly used for overdentures. The deleterious effects of exposure to magnetic flux on human health have not been substantiated so far; nevertheless, there is a need to understand the extent of magnetic field exposure in the oral area resulting from the use of magnetic attachments. The purpose of this study was to investigate the influence of a magnetic field on oral squamous cell carcinoma. Tumor cells cultured on a magnetic plate were compared with those not cultured on a magnetic plate (controls). The cells were seeded at a density of 1 × 105 cells/well and cultured for 6 days. The influence of the magnetic field on cytokine production was examined by cytokine array analysis. Secretion of platelet-derived growth factor-AA (PDGF-AA) was measured by enzyme-linked immunosorbent assay and Western blotting. The expression of PDGF-AA messenger RNA was examined by real-time polymerase chain reaction, whereas nuclear factor-kappa B activity was measured by luciferase assay. The results indicated that the magnetic field inhibited the secretion of PDGF-AA, thereby inhibiting PDGF-AA-induced expression, thus reducing the risk of cancer recurrence.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248630	Platelet-Derived Growth Factor-AA human			Price

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