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A Stem Cell-Based Approach to Cartilage Repair

A Stem Cell-Based Approach to Cartilage Repair

Kristen Johnson, Shoutian Zhu, Matthew S Tremblay, Joshua N Payette, Jianing Wang, Laure C Bouchez, Shelly Meeusen, Alana Althage, Charles Y Cho, Xu Wu, Peter G Schultz

Science. 2012 May 11;336(6082):717-21.

PMID: 22491093

Abstract:

Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that promote the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes may stimulate the repair of damaged cartilage. Using an image-based high-throughput screen, we identified the small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. This work provides new insights into the control of chondrogenesis that may ultimately lead to a stem cell-based therapy for osteoarthritis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4727315	Kartogenin		4727-31-5	Price

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