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A Study of a Supplement Containing Huperzine A and Curcumin in Dementia Patients and Individuals With Mild Cognitive Impairment

A Study of a Supplement Containing Huperzine A and Curcumin in Dementia Patients and Individuals With Mild Cognitive Impairment

Takeshi Tabira, Nobutoshi Kawamura

J Alzheimers Dis. 2018;63(1):75-78.

PMID: 29614668

Abstract:

Extracts from Huperzia serrata (HS) function as a cholinesterase inhibitor and a glutamic acid receptor antagonist. We tested a supplement containing HS extracts, curcumin, and others in dementia patients and individuals with mild cognitive impairment (MCI) in an open label study. Most patients with Alzheimer's disease, dementia with Lewy bodies, and MCI individuals exhibited improvements in cognitive functions, as assessed by the Alzheimer's Disease Assessment Scale-cognitive subscale Japanese version. The scores were significantly improved at 6-12 weeks compared with baseline scores (p = 0.007) and at 22-28 weeks (p = 0.004). Thus, this supplement may be administered to dementia patients as well as MCI individuals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP102518796-B	Huperzine A		102518-79-6	Price
AP120786187	(±)-Huperzine A		120786-18-7	Price

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