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A Study of Prostacyclin Mimetics Distinguishes Neuronal From Neutrophil IP Receptors

A Study of Prostacyclin Mimetics Distinguishes Neuronal From Neutrophil IP Receptors

H Wise, Y M Qian, R L Jones

Eur J Pharmacol. 1995 May 24;278(3):265-9.

PMID: 7589166

Abstract:

The prostacyclin mimetics BMY 45778 (3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid), BMY 42393 (2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid) and EP 185 (rac 5-endo-(6'-carboxyhex-2'Z-enyl)-6-exo-(p-methoxyphenyl- phenyl-methylazino)-bicyclo[2.2.2]oct-2-ene) inhibited rat neutrophil aggregation stimulated by N-formyl-methionyl-leucyl-phenylalanine (IC50 = 20, 462, and 1195 nM respectively). In contrast only BMY 45778 (1-10 microM) produced any significant inhibition (10-20%) of the spontaneous activity of rat colon. BMY 45778 (10 microM) also attenuated the inhibitory effect of the prostacyclin analogue cicaprost on rat colon, whereas BMY 42393 and EP 185 did not. BMY 45778 appears to be a low affinity partial agonist at prostacyclin receptors on rat colon and its low potency in rat colon compared with rat neutrophils suggests the presence of a different prostacyclin receptor located on enteric neurones.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP152575661	BMY 45778		152575-66-1	Price

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