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A Study of the Permeation of Dihexadecyl Phosphate Vesicles by Various Anesthetics

P E Ménassa, C Sandorfy

Biophys Chem. 1986 Dec 15;25(2):175-9.

PMID: 3814752

Abstract:

A simple spectroscopic method for the evaluation of the effect that perturbers may have on a membrane model is described. The model was made from dihexadecyl phosphate (DHP) bilayers. The perturbers used were unconventional anesthetics (n-alcohols C1-C8; n-hexane and n-pentane) and conventional anesthetics (chloroform, methoxyflurane, halothane and enflurane). The results show a correlation between vesicle permeation by anesthetics and their clinical potency. Two modes of perturbation by which the anesthetics may induce vesicle permeation are proposed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2197639 Dihexadecyl phosphate Dihexadecyl phosphate 2197-63-9 Price
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