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A Study on the Anti-Inflammatory Effects of New Derivatives of 3-hydroxy pyridine-4-one

A Study on the Anti-Inflammatory Effects of New Derivatives of 3-hydroxy pyridine-4-one

Valiollah Hajhashemi, Hoda Mojiri-Froshani, Lotfollah Saghaei, Afshin Fassihi

Adv Biomed Res. 2014 May 28;3:134.

PMID: 24949305

Abstract:

Background:
Derivatives of pyridine-4-one act as iron chelators and possess various pharmacological effects such as antifungal, antimalarial, antiviral, anti-inflammatory, and analgesic effects. The aim of our study was to evaluate the anti-inflammatory effects of the three new derivatives of pyridine-4-one.
Materials and methods:
Carrageenan-induced paw edema in rats and croton oil-induced ear edema in mice were used to evaluate the anti-inflammatry effects of three 3-hydroxy-pyridine-4-one derivatives (compounds A, B, and C). Compound A (10, 20 mg/kg), compound B (200, 400 mg/kg), and compound C (100, 200 mg/kg), vehicle (1 mL/kg), and indomethacin as standard drug (10 mg/kg) were injected intraperitoneally 30 min prior to carrageenan injection and 4 h later, the paw volume was measured using a mercury plethysmograph. The maximum dose of each test compound was used in the croton oil-induced ear edema test.
Results:
All compounds showed significant anti-inflammatory activity in both tests. On a molar basis, compound A had the greatest potency, which may be due to the presence of a benzyl group substitution on the pyridine ring.
Conclusions:
Because cyclooxygenase and lipoxygenase as key enzymes of the inflammation pathway are heme-dependent, it seems that the anti-inflammatory effect of derivatives of pyridine-4-one may be related to their iron chelating properties. However, more investigations are needed to find out their exact mechanism of actions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2882157	Indomethacin Related Compound A		2882-15-7	Price
AP74113	Indomethacin Related Compound B		74-11-3	Price

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