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A Sulphonylthiourea (BM 20) Related to Torasemide: A New Loop Diuretic With Relative Potassium-Sparing Properties

A Sulphonylthiourea (BM 20) Related to Torasemide: A New Loop Diuretic With Relative Potassium-Sparing Properties

B Masereel, M Schynts, J M Krzesinski, B Pirotte, G Rorive, J Delarge

J Pharm Pharmacol. 1993 Aug;45(8):720-4.

PMID: 7901370

Abstract:

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives, very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP72811735	Torsemide Related Compound A		72811-73-5	Price

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