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A Synthesis of 2-substituted 2-aminoethanol Derivatives Having Inhibitory Activity Against Protein Kinase C

T Iwasaki, H Yamazaki, T Nishitani, K Kondo, T Sato

Chem Pharm Bull (Tokyo). 1992 Jan;40(1):122-6.

PMID: 1576662

Abstract:

A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2- exo-methanol (4h) and 2-endo-hexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC50 values of 2 x 10(-5) and 1 x 10(-5) M, respectively, but not protein kinase A at a concentration of 1 x 10(-3) M. The structure-activity relationships are discussed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP699956 5-Norbornene-2-exo,3-exo-dimethanol 5-Norbornene-2-exo,3-exo-dimethanol 699-95-6 Price
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