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A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration

A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration

Soumyashree Das, Andrew B Goldstone, Hanjay Wang, Justin Farry, Gaetano D'Amato, Michael J Paulsen, Anahita Eskandari, Camille E Hironaka, Ragini Phansalkar, Bikram Sharma, Siyeon Rhee, Elya Ali Shamskhou, etc.

Cell. 2019 Feb 21;176(5):1128-1142.e18.

PMID: 30686582

Abstract:

Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to preserve tissue following vascular occlusion. Some patients with heart disease develop collateral coronary arteries, and this correlates with increased survival. However, it is not known how these collaterals develop or how to stimulate them. We demonstrate that neonatal mouse hearts use a novel mechanism to build collateral arteries in response to injury. Arterial endothelial cells (ECs) migrated away from arteries along existing capillaries and reassembled into collateral arteries, which we termed "artery reassembly". Artery ECs expressed CXCR4, and following injury, capillary ECs induced its ligand, CXCL12. CXCL12 or CXCR4 deletion impaired collateral artery formation and neonatal heart regeneration. Artery reassembly was nearly absent in adults but was induced by exogenous CXCL12. Thus, understanding neonatal regenerative mechanisms can identify pathways that restore these processes in adults and identify potentially translatable therapeutic strategies for ischemic heart disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248681	SDF-1alpha (CXCL12) from mouse			Price

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