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A Validation of the Danish Microbiology Database (MiBa) and Incidence Rate of Actinotignum Schaalii (Actinobaculum Schaalii) Bacteraemia in Denmark

A Validation of the Danish Microbiology Database (MiBa) and Incidence Rate of Actinotignum Schaalii (Actinobaculum Schaalii) Bacteraemia in Denmark

S Bank, K M Søby, L H Kristensen, M Voldstedlund, J Prag

Clin Microbiol Infect. 2015 Dec;21(12):1097.e1-4.

PMID: 26319901

Abstract:

Actinotignum schaalii (former named Actinobaculum schaalii) can cause urinary tract infections (UTIs) and bacteraemia, mainly in the elderly. A. schaalii is difficult to identify with conventional biochemical tests, and it is often overlooked if the urine is only cultured in ambient air. The aim of this study was to validate data from the nationwide Danish microbiology database (MiBa) with data from the laboratory information system (LIS) at the local department of microbiology in Viborg-Herning, and to evaluate the incidence rate of bacteraemia caused by A. schaalii in Denmark by using data from the MiBa. All departments of microbiology in Denmark report data to the MiBa. All microbiological samples with A. schaalii in Denmark were extracted for a period of 5 years from the MiBa and from the local LISs. All data obtained from our local LIS were also found in the MiBa, except for data on real-time PCR, which were not registered, owing to missing ID codes in the MiBa. From 2010 to 2014, there was a significant increase in the incidence rate of blood cultures with A. schaalii, from 1.8 to 6.8 cases per million, which was probably due to coincident implementation of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) in routine diagnostics. We found that A. schaalii caused bacteraemia and UTIs mainly in the elderly. In conclusion, the MiBa can be a useful source of nationwide microbiological data in Denmark. Our results suggest that the incidence rate of A. schaalii as a cause of bacteraemia has been underestimated, and that culture of urine in CO2 can improve the detection of A. schaalii.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP89694508	MIBA		89694-50-8	Price

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