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A Versatile Method for the Protection of Carbonyl Compounds by Camphor Sulfonic Acid

A Versatile Method for the Protection of Carbonyl Compounds by Camphor Sulfonic Acid

Ram Naresh Yadav, Bimal Krishna Banik

Curr Organocatal. 2018 Aug;5(3):196-200.

PMID: 31815094

Abstract:

Background:
Carbonyl groups are important functional groups and they play a key role in organic chemistry. This group needs to be protected in multistep synthesis against various reagents for a counter-reaction. The effort towards developing an efficient methodology for the protection of car-bonyl functional group is always a demanding reaction. The protection of carbonyl compounds for in-hibiting their chemical reactivity is an important operation in chemistry. In this paper, camphor sulfonic acid-catalysed protection of various carbonyl compounds is developed. This method is simple, envi-ronmentally friendly and yields products in high yields.
Method:
Commercially available camphor sulfonic acid is used as organo-catalyst for the protection of carbonyl functionality. This catalyst is also employed for the protection of carbonyl functionality as thi-oacetal/mixed ketal in excellent yield. The newly synthesize compounds are characterized using 1HNMR, 13C NMR and IR spectroscopy.
Result:
A diverse carbonyl functional group is protected in excellent yield under mild reaction condi-tions.
Conclusion:
We have developed an efficient organocatalysed protection method of carbonyl function-ality applicable to wide range of substrates.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3144169	D-Camphor sulfonic acid		3144-16-9	Price

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