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Abortifacient Efficiency of 15 (S) 15-methyl-prostaglandin F2alpha-methyl Ester Administered Vaginally During Early Pregnancy

Abortifacient Efficiency of 15 (S) 15-methyl-prostaglandin F2alpha-methyl Ester Administered Vaginally During Early Pregnancy

O Ylikorkala, P A Järvinen, M Puukka, L Viinikka

Prostaglandins. 1976 Oct;12(4):609-24.

PMID: 973006

Abstract:

Forty early pregnancies (menses delay 13 - 27 days) were terminated by administering four vaginal suppositoreis each containing 1.0 or 1.5 mg of 15 (S) 15-methyl-prostaglandin F2alpha-methyl ester, one every third hour. In 14 cases serial measurementsof serum estradiol and progesterone were performed during and after therapy. Uterine contractions and bleeding started 1 - 17 hours after administration of the first suppository. Abortion was complete after one week in five women (13%), and after two weeks in 30 (75%). A curettage was performed on eight women, residual placental fragments were found in seven and pregnancy continued in one woman. Mild diarrhoea (65%) and vomiting (40%) were the major side-effects, despite premedication. Estradiol and progesterone levels fell progressively during the therapy. Self-administration of 4 or 6 mg of the methyl ester caused too low a rate of complete abortion for use in practice, but it may be a valuable and practical agent for preoperative dilation of the cervix.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33854169	Prostaglandin F2α methyl ester		33854-16-9	Price

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