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Accumulation of Oleate-Rich Cholesteryl Esters by acetyl-LDL in Macrophages in the Presence of an acyl-CoA: Cholesterol Acyltransferase Inhibitor (Sandoz 58-035)

Accumulation of Oleate-Rich Cholesteryl Esters by acetyl-LDL in Macrophages in the Presence of an acyl-CoA: Cholesterol Acyltransferase Inhibitor (Sandoz 58-035)

O Shimasaki, C Mineo, H Mowri, S Ohkuma, T Takano

Biochem Int. 1990;20(2):389-96.

PMID: 2317217

Abstract:

The mechanism through which cholesteryl esters rich in oleic acid accumulate in the cytoplasm was studied. The fatty acid composition of the cholesteryl esters in acetyl-LDL was high in linoleic acid, while that of cholesteryl ester inclusion bodies accumulated in the cytoplasm was high in oleic acid. This compositional change of fatty acids in cholesteryl esters occurred even in the presence of an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, Sandoz 58-035. These results suggest that oleate-rich cholesteryl esters accumulated in the cytoplasm, even though the reesterification in microsome was inhibited by an ACAT inhibitor.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78934835	Sandoz 58-035		78934-83-5	Price

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