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Accumulation of Porphyrins in Propionibacterium Acnes by 5-aminolevulinic Acid and Its Esters

Accumulation of Porphyrins in Propionibacterium Acnes by 5-aminolevulinic Acid and Its Esters

Arisa Ogata, Yuya Hasunuma, Emii Kikuchi, Takuya Ishii, Masahiro Ishizuka, Yoshikazu Tokuoka

Photodiagnosis Photodyn Ther. 2017 Sep;19:167-169.

PMID: 28624551

Abstract:

We have investigated the accumulation of porphyrins in Propionibacterium acnes (P.acnes) by 5-aminolevulinic acid hydrochloride (ALA) and its esters, ALA methyl ester hydrochloride (mALA), ALA octyl ester hydrochloride (oALA), and ALA benzyl ester hydrochloride (bALA). From the fluorescence spectra of porphyrins accumulated in P.acnes, the order of porphyrin accumulation is as follows: ALA≫mALA≈bALA>oALA (≈0). Moreover, the PDT efficacy is reduced in the order of ALA>mALA≈bALA>oALA (≈without additives). These results confirm that ALA is superior to ALA esters in accumulating porphyrins in P.acnes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5451092-B	5-Aminolevulinic acid hydrochloride		5451-09-2	Price

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