0

[Acetate-free Bicarbonate Dialysate: Which Acid in the Dialysis Buffer?]

Myriam Dao, Malik Touam, Dominique Joly, Lucile Mercadal

Nephrol Ther. 2019 Apr;15 Suppl 1:S91-S97.

PMID: 30981402

Abstract:

The mix of bicarbonate and divalent cations requires a small amount of acid to avoid insoluble precipitation in the dialysate buffer. Small doses of acetic acid (3-7 mmol/L) are commonly used. Acetic acid may be replaced by hydrochloric acid or citric acid to achieve acetate-free haemodialysis. Hydrochloric acid theoretically avoids metabolic side effects of acetate. However, additional cost generated by technical constraints probably slowed its generalization. Citric acid has been proposed as a more biocompatible acidifier than acetic acid. By binding calcium, citric acid inhibits both coagulation and complement activation and may reduce the treatment-induced inflammatory response. However, results of the study are conflicting, especially regarding impact on calcium and phosphate metabolism and acid-base metabolism. On the basis of current findings, systematic replacement of acetic acid by citric acid cannot be proposed for all the patients.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP118409668 α-Cyano-4-fluorocinnamic acid α-Cyano-4-fluorocinnamic acid 118409-66-8 Price
AP17660514 Stearic-d35 acid Stearic-d35 acid 17660-51-4 Price
AP215527701 Phenyl-d5-boronic acid Phenyl-d5-boronic acid 215527-70-1 Price
AP374538019 4-Fluoro-3-formylphenylboronic acid 4-Fluoro-3-formylphenylboronic acid 374538-01-9 Price
AP39756326 Eicosanoic-d39 Acid Eicosanoic-d39 Acid 39756-32-6 Price
AP4671823 Propylenediphosphonic acid Propylenediphosphonic acid 4671-82-3 Price
AP480424611 Fluorene-2-boronic acid Fluorene-2-boronic acid 480424-61-1 Price
AP59154437 Lauric-d23 acid Lauric-d23 acid 59154-43-7 Price
AP63076517 Cyclopentylboronic acid Cyclopentylboronic acid 63076-51-7 Price
AP68572872 9-Phenanthracenylboronic acid 9-Phenanthracenylboronic acid 68572-87-2 Price
qrcode