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Acetyl-α-boswellic Acid and Acetyl-β-boswellic Acid Protects Against Caerulein-Induced Pancreatitis via Down-Regulating MAPKs in Mice

Acetyl-α-boswellic Acid and Acetyl-β-boswellic Acid Protects Against Caerulein-Induced Pancreatitis via Down-Regulating MAPKs in Mice

Pan-Yang Zhang, Bin Yu, Wei-Jie Men, Ru-Yu Bai, Meng-Ying Chen, Zhao-Xin Wang, Tao Zeng, Kun Zhou

Int Immunopharmacol. 2020 Jun 18;86:106682.

PMID: 32563781

Abstract:

This study is to investigate the protective effect of Acetyl-α-boswellic acid and Acetyl-β-boswellic mixture(α/β-ABA), which is the active ingredients isolated from Frankincense, on actue pancreatitis and its mechanism. Our experimental results showed that 2 μM α/β-ABA reduced production of NO, TNF-α, IL-6, IL-10 and IL-1β in RAW264.7 cells that were stimulated with lipopolysaccharide (LPS) which indicates its anti-inflammatory role. In pancreatitis model induced by caerulein, intra-gastrical administration of 100 mg/kg α/β-ABA relieved inflammatory cells infiltration significantly and attenuated the serum elevation of amylase TNF-α and IL-6 remarkably in mice. Furthermore, α/β-ABA down-regulated mitogen-activated protein kinase (MAPK) family phosphorylated proteins in pancreas, including phosphorylated p38, ERK1/2 and JNK, to reduce the serum inflammatory factors. Finally, α/β-ABA alleviated the pancreatic edema and inflammatory cell infiltration in pancreatitis mice model. This study suggests that α/β-ABA may be targeted for drug development against pancreatitis via modulating MAPKs pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP471669	α-Boswellic acid		471-66-9	Price
CS3102180	Boswellic acid, mixture of α and β			Price

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