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Acid-catalyzed Reactions of 3-hydroxy-2-oxindoles With Electron-Rich Substrates: Synthesis of 2-oxindoles With All-Carbon Quaternary Center

Lakshmana K Kinthada, Santanu Ghosh, Subhadip De, Subhajit Bhunia, Dhananjay Dey, Alakesh Bisai

Org Biomol Chem. 2013 Sep 25;11(40):6984-93.

PMID: 24057328

Abstract:

A Lewis acid catalyzed reaction of in situ generated 2H-indol-2-one () with various 2π and other electron-rich substrates has been developed. A variety of electron-rich substrates such as allyl/methallyltrimethylsilane, phenylacetylene, styrenes, acetophenone, and indoles have been used. The methodology provides a straightforward approach for the synthesis of 2-oxindoles with an all-carbon quaternary center at the pseudobenzylic position.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP18292381 Methallyltrimethylsilane Methallyltrimethylsilane 18292-38-1 Price
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